Alzheimer’s disease is a global health problem with more than 5.8 million people living with the disease in the United States alone. The only way to solve that problem is through research, and this talk will focus on the scientific advancements and progress in the field. Tremendous gains have been made in the understanding of the science and basic biology underlying Alzheimer’s disease and dementia, and these advances are leading to great strides in prevention, detection, diagnostics and therapeutic interventions.